Diagnostic potential of IL6 and other blood-based inflammatory biomarkers in mild traumatic brain injury among children.

ABSTRACT:

Objectives

Inflammatory biomarkers, as indicators of biological states, provide a valuable approach for accurate and reproducible measurements, crucial for the effective management of mild traumatic brain injury (mTBI) in pediatric patients. This study aims to assess the diagnostic utility of blood-based inflammatory markers IL6, IL8, and IL10 in children with mTBI, including those who did not undergo computed tomography (CT) scans.

Methods

A prospective multicentric cohort study involving 285 pediatric mTBI patients was conducted, stratified into CT-scanned and non-CT-scanned groups within 24 h post-trauma, alongside 74 control subjects. Biomarker levels were quantitatively analyzed using ELISA. Sensitivity and specificity metrics were calculated to determine the diagnostic

SUBMITTER: Chiollaz AC 

PROVIDER: S-EPMC11270961 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature