Small duct and large duct type intrahepatic cholangiocarcinoma reveal distinct patterns of immune signatures.

ABSTRACT:

Purpose

Dedicated gene signatures in small (SD-iCCA) and large (LD-iCCA) duct type intrahepatic cholangiocarcinoma remain unknown. We performed immune profiling in SD- and LD-iCCA to identify novel biomarker candidates for personalized medicine.

Methods

Retrospectively, 19 iCCA patients with either SD-iCCA (n = 10, median age, 63.1 years (45-86); men, 4) or LD-iCCA (n = 9, median age, 69.7 years (62-85); men, 5)) were included. All patients were diagnosed and histologically confirmed between 04/2009 and 01/2021. Tumor tissue samples were processed for differential expression profiling using NanoString nCounter® PanCancer Immune Profiling Panel.

Results

With the exception of complement signatures, immune-related pathways were broadly downregulated in SD-iCCA vs. LD-iCC

SUBMITTER: Bernatz S 

PROVIDER: S-EPMC11271402 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature