Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety.

ABSTRACT: There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We used task-free and task-evoked data from a standardized functional magnetic resonance imaging protocol conducted across multiple studies in patients with depression and anxiety when treatment free (n = 801) and after randomization to pharmacotherapy or behavioral therapy (n = 250). From these patients, we derived personalized and interpretable scores of brain circuit dysfunction grounded in a theoretical taxonomy. Participants were subdivided into six biotypes defined by distinct profiles of intrinsic task-free functional connectivity within the default mode, salience and frontoparietal attention circuits,

SUBMITTER: Tozzi L 

PROVIDER: S-EPMC11271415 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature