Adenosine Triphosphate Release From Influenza-Infected Lungs Enhances Neutrophil Activation and Promotes Disease Progression.

ABSTRACT:

Background

Adenosine triphosphate (ATP) enhances neutrophil responses, but little is known about the role of ATP in influenza infections.

Methods

We used a mouse influenza model to study if ATP release is associated with neutrophil activation and disease progression.

Results

Influenza infection increased pulmonary ATP levels 5-fold and plasma ATP levels 3-fold vs healthy mice. Adding ATP at those concentrations to blood from healthy mice primed neutrophils and enhanced CD11b and CD63 expression, CD62L shedding, and reactive oxygen species production in response to formyl peptide receptor stimulation. Influenza infection also primed neutrophils in vivo, resulting in formyl peptide receptor-induced CD11b expression and CD62L shedding up to 3 times higher than that of un

SUBMITTER: Ledderose C 

PROVIDER: S-EPMC11272046 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature