Comparing cohort and period trends of early-onset colorectal cancer: a global analysis.

ABSTRACT:

Background

Incidence of early-onset colorectal cancer (CRC) has increased globally in recent decades. We examined early-onset CRC incidence trends worldwide for potential cohort effects, defined as changes associated with time of birth (eg, early-life exposure to carcinogens), and period effects, defined as changes associated with calendar periods (eg, screening programs).

Methods

We obtained long-term incidence data for early-onset CRC diagnosed in patients aged 20 to 49 years through the year 2012 for 35 countries in the Cancer Incidence in Five Continents database. We used a smoothing method to help compare cohort and period trends of early-onset CRC and used an age-period-cohort model to estimate cohort and period effects.

Results

Cohort effects had a more dominan

SUBMITTER: Chen J 

PROVIDER: S-EPMC11272173 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature