Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders.

ABSTRACT:

Background

Anhedonia is characterized by a reduced ability to anticipate, experience, and/or learn about pleasure. This phenomenon has a transdiagnostic nature and is one of the key symptoms of mood disorders, schizophrenia, addictions, and somatic conditions.

Aim

To evaluate the genetic architecture of anhedonia and its overlap with other mental disorders and somatic conditions.

Methods

We performed a genome-wide association study of anhedonia on a sample of 4,520 individuals from a Russian non-clinical population. Using the available summary statistics, we calculated polygenic risk scores (PRS) to investigate the genetic relationship between anhedonia and other psychiatric or somatic phenotypes.

Results

No variants with a genome-wide significant association w

SUBMITTER: Kasyanov E 

PROVIDER: S-EPMC11272301 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature