Antibiotic Use in the 12 Months Prior to Ileal Pouch-Anal Anastomosis Increases the Risk for Pouchitis.

ABSTRACT:

Background & aims

Pouchitis is the most common complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC); however, clinical and environmental risk factors for pouchitis remain poorly understood. We explored the relationship between specific clinical factors and the incidence of pouchitis.

Methods

We established a population-based cohort of all adult persons in Denmark undergoing proctocolectomy with IPAA for UC from 1996-2020. We used Cox proportional hazard modeling to assess the impact of antibiotic, nonsteroidal anti-inflammatory drug (NSAID) exposure, and appendectomy on diagnosis of acute pouchitis in the first 2 years after IPAA surgery.

Results

Among 1616 eligible patients, 46% developed pouchitis in the first 2 years after IPAA. Antibi

SUBMITTER: Barnes EL 

PROVIDER: S-EPMC11272433 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature