The causal relationship between gut microbiota and alopecia areata: a Mendelian randomization analysis.

ABSTRACT:

Background

Increasing evidence suggests a robust correlation between the gut microbiome and alopecia areata. In light of the extensive diversity of gut microbiota, this study aims to utilize state-of-the-art and comprehensive data to explore the causative association between gut microbiota and alopecia areata.

Objective

We conducted a Mendelian randomization (MR)-based two-sample study to elucidate the causal relationship between gut microbiota and alopecia areata.

Method

Summary information on Ncase = 767 and Ncontrol = 394,105 cases of alopecia areata was obtained from the FinnGen study. A total of 473 gut microbial taxa were summarized from the genome-wide association study (GWAS) catalog. The study comprised a forward Mendelian randomization (MR) analysis with the

SUBMITTER: Bi D 

PROVIDER: S-EPMC11272542 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature