Stromal cell-expressed malignant gene patterns contribute to the progression of squamous cell carcinomas across different sites.

ABSTRACT:

Background

Squamous cell carcinomas (SCCs) across different anatomical locations possess common molecular features. Recent studies showed that stromal cells may contribute to tumor progression and metastasis of SCCs. Limited by current sequencing technology and analysis methods, it has been difficult to combine stroma expression profiles with a large number of clinical information.

Methods

With the help of transfer learning on the cell line, single-cell, and bulk tumor sequencing data, we identified and validated 2 malignant gene patterns (V1 and V5) expressed by stromal cells of SCCs from head and neck (HNSCC), lung (LUSC), cervix (CESC), esophagus, and breast.

Results

Pattern V5 reflected a novel malignant feature that explained the mixed signals of HNSCC molecular

SUBMITTER: Qi K 

PROVIDER: S-EPMC11272565 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature