A novel basement membrane-related gene signature predicts prognosis and immunotherapy response in hepatocellular carcinoma.

ABSTRACT:

Background

Basement membranes (BMs) have recently emerged as significant players in cancer progression and metastasis, rendering them promising targets for potential anti-cancer therapies. Here, we aimed to develop a novel signature of basement membrane-related genes (BMRGs) for the prediction of clinical prognosis and tumor microenvironment in hepatocellular carcinoma (HCC).

Methods

The differentially expressed BMRGs were subjected to univariate Cox regression analysis to identify BMRGs with prognostic significance. A six-BMRGs risk score model was constructed using Least Absolute Shrinkage Selection Operator (LASSO) Cox regression. Furthermore, a nomogram incorporating the BMRGs score and other clinicopathological features was developed for accurate prediction of survival

SUBMITTER: Li B 

PROVIDER: S-EPMC11272612 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature