Comprehensive analysis of aberrantly methylated differentially expressed genes and validation of CDC6 in melanoma.

ABSTRACT:

Background

Skin Cutaneous Melanoma (SKCM) is a highly aggressive malignant tumor with a significant increase in mortality upon metastasis. The molecular mechanisms driving melanoma progression remain largely unclear. Recent studies have highlighted the importance of epigenetic alterations, especially DNA methylation, in melanoma development. This study aims to identify and analyze methylation-regulated differentially expressed genes (MeDEGs) in genome-wide profiles between primary and metastatic melanoma.

Methods

Gene expression profiling datasets GSE8401 and gene methylation profiling datasets GSE86355 were collected from the GEO database. Differentially expressed genes (DEGs) and differentially methylated genes (DMGs) were systematically identified. Integration of DEGs and

SUBMITTER: Liao L 

PROVIDER: S-EPMC11272740 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature