Primary SARS-CoV-2 infection in children and adults results in similar Fc-mediated antibody effector function patterns.

ABSTRACT:

Objectives

Increasing evidence suggests that Fc-mediated antibody effector functions have an important role in protection against respiratory viruses, including SARS-CoV-2. However, limited data are available on the potential differences in the development, heterogeneity and durability of these responses in children compared to adults.

Methods

Here, we assessed the development of spike S1-specific serum antibody-dependent cellular phagocytosis (ADCP), complement deposition (ADCD) and natural killer cell activation (ADNKA), alongside specific antibody binding concentrations (IgG, IgA and IgM) and IgG avidity in healthy adults (n = 38, 18-56 years) and children (n = 21, 5-16 years) following primary SARS-CoV-2 infection, with a 10-month longitudinal follow-up. Di

SUBMITTER: Gelderloos AT 

PROVIDER: S-EPMC11273100 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature