Flow cytometry-based diagnostic approach for inborn errors of immunity: experience from Algeria.

ABSTRACT:

Purpose

In this study, we retrospectively reviewed the use of flow cytometry (FCM) in the diagnosis of inborn errors of immunity (IEIs) at a single center in Algeria. Sharing insights into our practical experience, we present FCM based diagnostic approaches adapted to different clinical scenarios.

Methods

Between May 2017 and February 2024, pediatric and adult patients presenting with clinical features suggestive of immunodeficiency were subjected to FCM evaluation, including lymphocyte subset analysis, detection of specific surface or intracellular proteins, and functional analysis of immune cells.

Results

Over a nearly seven-year period, our laboratory diagnosed a total of 670 patients (372 (55.5%) males and 298 (44.5%) females), distributed into 70 different IEIs b

SUBMITTER: Tahiat A 

PROVIDER: S-EPMC11273131 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature