Reverse Vaccinology Approach to Identify Novel and Immunogenic Targets against Streptococcus gordonii.

ABSTRACT: Streptococcus gordonii is a gram-positive, mutualistic bacterium found in the human body. It is found in the oral cavity, upper respiratory tract, and intestines, and presents a serious clinical problem because it can lead to opportunistic infections in individuals with weakened immune systems. Streptococci are the most prevalent inhabitants of oral microbial communities, and are typical oral commensals found in the human oral cavity. These streptococci, along with many other oral microbes, produce multispecies biofilms that can attach to salivary pellicle components and other oral bacteria via adhesin proteins expressed on the cell surface. Antibiotics are effective against this bacterium, but resistance against antibodies is increasing. Therefore, a more effective treatment is nee

SUBMITTER: Abid A 

PROVIDER: S-EPMC11274250 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature