Anti-Inflammatory and Cancer-Preventive Potential of Chamomile (<i>Matricaria chamomilla</i> L.): A Comprehensive In Silico and In Vitro Study.

ABSTRACT:

Background and aim

Chamomile tea, renowned for its exquisite taste, has been appreciated for centuries not only for its flavor but also for its myriad health benefits. In this study, we investigated the preventive potential of chamomile (Matricaria chamomilla L.) towards cancer by focusing on its anti-inflammatory activity.

Methods and results

A virtual drug screening of 212 phytochemicals from chamomile revealed β-amyrin, β-eudesmol, β-sitosterol, apigenin, daucosterol, and myricetin as potent NF-κB inhibitors. The in silico results were verified through microscale thermophoresis, reporter cell line experiments, and flow cytometric determination of reactive oxygen species and mitochondrial membrane potential. An oncobiogram generated through comparison of 91 anticanc

SUBMITTER: Drif AI 

PROVIDER: S-EPMC11275008 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature