Longitudinal Genome-Wide Association Study of Cognitive Impairment after Subarachnoid Hemorrhage.

ABSTRACT:

Objectives

The occurrence of cognitive deficits after subarachnoid hemorrhage (SAH) is highly possible, leading to vascular dementia. We performed a novel longitudinal genome-wide association study (GWAS) to identify genetic modifications associated with cognitive impairment following SAH in a long-term prospective cohort study.

Materials and methods

This GWAS involved 153 patients with SAH sharing 5,971,372 markers after high-throughput imputation. Genome-wide Cox proportional hazard regression testing was performed to estimate the hazard ratio (HR) and 95% confidence interval (CI). Subsequently, a weighted polygenetic risk score (wPRS) was determined, based on GWAS-driven loci and risk stratification.

Results

Cognitive impairment was observed in 65 patients (42.5%)

SUBMITTER: Hong EP 

PROVIDER: S-EPMC11275094 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature