<i>Ex vivo</i> susceptibility to antimalarial drugs and polymorphisms in drug resistance genes of African <i>Plasmodium falciparum</i>, 2016-2023: a genotype-phenotype association study.

ABSTRACT:

Background

Given the altered responses to both artemisinins and lumefantrine in Eastern Africa, monitoring antimalarial drug resistance in all African countries is paramount.

Methods

We measured the susceptibility to six antimalarials using ex vivo growth inhibition assays (IC₅₀) for a total of 805 Plasmodium falciparum isolates obtained from travelers returning to France (2016-2023), mainly from West and Central Africa. Isolates were sequenced using molecular inversion probes (MIPs) targeting fourteen drug resistance genes across the parasite genome.

Findings

Ex vivo susceptibility to several drugs has significantly decreased in 2019-2023 versus 2016-2018 parasite samples: lumefantrine (median IC₅₀: 23·0 nM [IQR: 14·4-35·1]

SUBMITTER: Rosado J 

PROVIDER: S-EPMC11275679 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature