Oral citrate supplementation mitigates age-associated pathological intervertebral disc calcification in LG/J mice.

ABSTRACT: Despite the high prevalence of age-dependent intervertebral disc calcification, there is a glaring lack of treatment options for this debilitating pathology. Here, we investigate the efficacy of long-term oral K₃Citrate supplementation in ameliorating disc calcification in LG/J mice, a model of spontaneous age-associated disc calcification. K₃Citrate successfully reduced the incidence of disc calcification in LG/J mice without deleterious effects on vertebral bone structure, plasma chemistry, and locomotion. Notably, a positive effect on grip strength was evident in treated mice. Spectroscopic investigation of the persisting calcified nodules indicated K₃Citrate did not alter the mineral composition and revealed that reactivation of an endochondral differen

SUBMITTER: Ottone OK 

PROVIDER: S-EPMC11275755 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature