Peripheral Ca_V2.2 channels in skin regulate prolonged heat hypersensitivity during neuroinflammation.

ABSTRACT: Neuroinflammation can lead to chronic maladaptive pain affecting millions of people worldwide. Neurotransmitters, cytokines, and ion channels are implicated in neuro-immune cell signaling but their roles in specific behavioral responses are not fully elucidated. Voltage-gated Ca_V2.2 channel activity in skin controls rapid and transient heat hypersensitivity induced by intradermal capsaicin via IL-1α cytokine signaling. Ca_V2.2 channels are not, however, involved in mechanical hypersensitivity that developed in the same animal model. Here, we show that Ca_V2.2 channels are also critical for heat hypersensitivity induced by the intradermal (id) Complete Freund's Adjuvant (CFA) model of chronic neuroinflammation that involves ongoing cytokine signaling fo

SUBMITTER: Salib AN 

PROVIDER: S-EPMC11275762 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature