HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos.

ABSTRACT: Human fertility is suboptimal, partly due to error-prone divisions in early cleavage-stages that result in aneuploidy. Most human pre-implantation are mosaics of euploid and aneuploid cells, however, mosaic embryos with a low proportion of aneuploid cells have a similar likelihood of developing to term as fully euploid embryos. How embryos manage aneuploidy during development is poorly understood. This knowledge is crucial for improving fertility treatments and reducing developmental defects. To explore these mechanisms, we established a new mouse model of chromosome mosaicism to study the fate of aneuploid cells during pre-implantation development. We previously used the Mps1 inhibitor reversine to generate aneuploidy in embryos. Here, we found that treatment with the more specific Mps1 i

SUBMITTER: Sanchez-Vasquez E 

PROVIDER: S-EPMC11275769 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature