Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A.

ABSTRACT: Following prolonged activity blockade, amplitudes of miniature excitatory postsynaptic currents (mEPSCs) increase, a form of plasticity termed "homeostatic synaptic plasticity." We previously showed that a presynaptic protein, the small GTPase Rab3A, is required for full expression of the increase in miniature endplate current amplitudes following prolonged blockade of action potential activity at the mouse neuromuscular junction in vivo, where an increase in postsynaptic receptors does not contribute (Wang et al., 2005; Wang et al., 2011). It is unknown whether this form of Rab3A-dependent homeostatic plasticity at the neuromuscular junction shares any characteristics with central synapses. We show here that homeostatic synaptic plasticity of mEPSCs is impaired in mouse cortical neuron cu

SUBMITTER: Koesters AG 

PROVIDER: S-EPMC11275788 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature