AoUPRS: A Cost-Effective and Versatile PRS Calculator for the <i>All of Us</i> Program.

ABSTRACT:

Background

The All of Us (AoU) Research Program provides a comprehensive genomic dataset to accelerate health research and medical breakthroughs. Despite its potential, researchers face significant challenges, including high costs and inefficiencies associated with data extraction and analysis. AoUPRS addresses these challenges by offering a versatile and cost-effective tool for calculating polygenic risk scores (PRS), enabling both experienced and novice researchers to leverage the AoU dataset for significant genomic discoveries.

Results

AoUPRS is implemented in Python and utilizes the Hail framework for genomic data analysis. It offers two distinct approaches for PRS calculation: the Hail MatrixTable (MT) and the Hail Variant Dataset (VDS). The MT approach provides a dense

SUBMITTER: Khattab A 

PROVIDER: S-EPMC11275801 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature