Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysis.

ABSTRACT: Immune-mediated diseases are characterized by aberrant immune responses, posing significant challenges to global health. In both inflammatory and autoimmune diseases, dysregulated immune reactions mediated by tissue-residing immune and non-immune cells precipitate chronic inflammation and tissue damage that is amplified by peripheral immune cell extravasation into the tissue. Chemokine receptors are pivotal in orchestrating immune cell migration, yet deciphering the signaling code across cell types, diseases and tissues remains an open challenge. To delineate disease-specific cell-cell communications involved in immune cell migration, we conducted a meta-analysis of publicly available single-cell RNA sequencing (scRNA-seq) data across diverse immune diseases and tissues. Our comprehensive

SUBMITTER: Rahman MF 

PROVIDER: S-EPMC11275869 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature