Spatial constraints and cell surface molecule depletion structure a randomly connected learning circuit.

ABSTRACT: The brain can represent almost limitless objects to "categorize an unlabeled world" (Edelman, 1989). This feat is supported by expansion layer circuit architectures, in which neurons carrying information about discrete sensory channels make combinatorial connections onto much larger postsynaptic populations. Combinatorial connections in expansion layers are modeled as randomized sets. The extent to which randomized wiring exists in vivo is debated, and how combinatorial connectivity patterns are generated during development is not understood. Non-deterministic wiring algorithms could program such connectivity using minimal genomic information. Here, we investigate anatomic and transcriptional patterns and perturb partner availability to ask how Kenyon cells, the expansion layer neur

SUBMITTER: Thornton-Kolbe EM 

PROVIDER: S-EPMC11275898 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature