Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies.

ABSTRACT: Human immunodeficiency virus (HIV)-1 evolves within individual hosts to escape adaptive immune responses while maintaining its capacity for replication. Coevolution between HIV-1 and the immune system generates extraordinary viral genetic diversity. In some individuals, this process also results in the development of broadly neutralizing antibodies (bnAbs) that can neutralize many viral variants, a key focus of HIV-1 vaccine design. However, a general understanding of the forces that shape virus-immune coevolution within and across hosts remains incomplete. Here we performed a quantitative study of HIV-1 evolution in humans and rhesus macaques, including individuals who developed bnAbs. We observed strong selection early in infection for mutations affecting HIV-1 envelope glycosylation and

SUBMITTER: Shimagaki KS 

PROVIDER: S-EPMC11275900 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature