Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations.

ABSTRACT: Striatal acetylcholine (ACh) signaling has been proposed to counteract reinforcement signals to promote extinction and behavioral flexibility. ACh dips to cues and rewards may open a temporal window for associative plasticity to occur, while elevations may promote extinction. Changes in multi-phasic striatal ACh signals have been widely reported during learning, but how and where signals are distributed to enable region-specific plasticity for the learning and degradation of cue-reward associations is poorly understood. We used array fiber photometry in mice to investigate how ACh release across the striatum evolves during learning and extinction of Pavlovian associations. We report a topographic organization of opposing changes in ACh release to cues, rewards, and consummatory actions acr

SUBMITTER: Bouabid S 

PROVIDER: S-EPMC11275942 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature