Genetic Ancestry and Self-Reported "Skin Color/Race" in the Urban Admixed Population of Sao Paulo City, Brazil.

ABSTRACT: Epidemiological studies frequently classify groups based on phenotypes like self-reported skin color/race, which inaccurately represent genetic ancestry and may lead to misclassification, particularly among individuals of multiracial backgrounds. This study aimed to characterize both global and local genome-wide genetic ancestries and to assess their relationship with self-reported skin color/race in an admixed population of Sao Paulo city. We analyzed 226,346 single-nucleotide polymorphisms from 841 individuals participating in the population-based ISA-Nutrition study. Our findings confirmed the admixed nature of the population, demonstrating substantial European, significant Sub-Saharan African, and minor Native American ancestries, irrespective of skin color. A correlation was observed

SUBMITTER: Pereira JL 

PROVIDER: S-EPMC11276533 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature