Variations of VEGFR2 Chemical Space: Stimulator and Inhibitory Peptides.

ABSTRACT: The kinase pathway plays a crucial role in blood vessel function. Particular attention is paid to VEGFR type 2 angiogenesis and vascular morphogenesis as the tyrosine kinase pathway is preferentially activated. In silico studies were performed on several peptides that affect VEGFR2 in both stimulating and inhibitory ways. This investigation aims to examine the molecular properties of VEGFR2, a molecule primarily involved in the processes of vasculogenesis and angiogenesis. These relationships were defined by the interactions between Vascular Endothelial Growth Factor receptor 2 (VEGFR2) and the structural features of the systems. The chemical space of the inhibitory peptides and stimulators was described using topological and energetic properties. Furthermore, chimeric models of stimulatin

SUBMITTER: Lungu CN 

PROVIDER: S-EPMC11276785 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature