Target Enzymes of Origanum majorana and Rosmarinus officinalis Essential Oils in Black Cutworm (Agrotis ipsilon): In Vitro and In Silico Studies.

ABSTRACT: In this study, in vitro and in silico approaches were employed to assess the toxicity of marjoram (Origanum majorana) and rosemary (Rosmarinus officinalis) essential oils (EOs) to A. ipsilon larvae. The study determined the activities of ATPases in the larvae after treatment with the LC₂₀ and LC₇₀ of each EO. α-esterase and glutathione-S-transferase (GST) activities were also determined after treatment with LC₁₀ and LC₃₀ of each EO. Furthermore, molecular docking was employed to determine the binding affinity of terpinene-4-ol and α-pinene, the major constituents of O. majorana, and R. officinalis EOs, respectively, compared to the co-crystallized ligand of α-esterase, diethyl hydrogen phosphate (DPF). Toxicity

SUBMITTER: Ahmed FS 

PROVIDER: S-EPMC11276864 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature