Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis.

ABSTRACT: Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied populations and developing countries. Instead, diagnosis is based on a combination of medical history, physical examination, cognitive testing, and brain imaging. Exosomes are extracellular nanovesicles, primarily composed of RNA, that participate in physiological processes related to AD pathogenesis such as cell proliferation, immune response, and neuronal and cardiovascular function. However, the identification and understanding of the potential role of long non-coding RNAs (lncRNAs) in AD diagnosis remain largely unexplored. Here, we clinically, cognitively, and gene

SUBMITTER: Mosquera-Heredia MI 

PROVIDER: S-EPMC11277322 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature