Identification of Axinellamines A and B as Anti-Tubercular Agents.

ABSTRACT: Tuberculosis remains a significant global health pandemic. There is an urgent need for new anti-tubercular agents to combat the rising incidence of drug resistance and to offer effective and additive therapeutic options. High-throughput screening of a subset of the NatureBank marine fraction library (n = 2000) identified a sample derived from an Australian marine sponge belonging to the order Haplosclerida that displayed promising anti-mycobacterial activity. Bioassay-guided fractionation of the organic extract from this Haplosclerida sponge led to the purification of previously identified antimicrobial pyrrole alkaloids, axinellamines A (1) and B (2). The axinellamine compounds were found to have a 90% minimum inhibitory concentration (MIC₉₀) of 18 µM and 1

SUBMITTER: Strong EJ 

PROVIDER: S-EPMC11277618 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature