A do-it-yourself benchtop device for highly scalable flow synthesis of protein-based nanoparticles.

ABSTRACT: Synthesis of nanoparticles is typically carried out in batch procedures, which offer limited control of parameters, and a narrow range of possible batch volumes. In contrast, flow synthesis systems, usually having a microfluidic chip as a crucial part, are devoid of these drawbacks. However, large scale devices - millifluidic systems - may offer several advantages over microfluidic systems, such as easier and cheaper production, enhanced throughput, and reduced channel clogging. Here we report a millifluidic system for the generation of protein nanoparticles, using the flow format of the original swift thermal formation technology (STF), which can process batch volume ranging from 100 µl to any practically significant amount. Capabilities of the system are demonstrated with model synthesis

SUBMITTER: Korenkov ES 

PROVIDER: S-EPMC11278078 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature