Genomic Characterization of a Clinical NDM-1-Producing Klebsiella michiganensis from Brazil.

ABSTRACT: Public health faces daily challenges due to increasing reports of pathogenic microorganisms with new antimicrobial resistance. Klebsiella michiganensis, an emerging pathogen, poses difficulty in its identification using conventional techniques. This study presents the first documented case of NDM-1-producing K. michiganensis in Brazil, identified as the new ST418. Initially, the isolate from a tracheal secretion was misidentified as K. oxytoca. However, accurate identification was achieved through ANI analyses. Whole-genome sequencing was conducted to characterize the genetic context of the resistance genes, to identify virulence factors, and to construct a phylogenetic tree. The bla_NDM-1 gene was found to be harbored on an IncFIB plasmid approximatel

SUBMITTER: Yamada AY 

PROVIDER: S-EPMC11278599 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature