Maternal obesity alters fetal neuroinflammation in a murine model of preterm birth.

ABSTRACT:

Background

Preterm birth from intrauterine infection is a leading cause of neonatal neurologic morbidity. Likewise, maternal obesity is associated with intra-amniotic infection and inflammation. Whether maternal obesity is a risk factor for fetal brain injury that occurs with premature birth remains unknown. This study hypothesized that maternal obesity intensifies fetal neuroinflammation in the setting of premature delivery.

Objective

This study aimed to examine the influence of maternal obesity on perinatal neuroinflammatory responses that arise with preterm birth using a murine model.

Study design

Dams with obesity were generated via a high-fat diet that was maintained throughout pregnancy. In parallel, dams without obesity (normal) received a control diet. All dam

SUBMITTER: Leonard KM 

PROVIDER: S-EPMC11278798 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature