Universal Lineage-Independent Markers of Multidrug Resistance in Mycobacterium tuberculosis.

ABSTRACT: (1) Background: This study was aimed to identify universal genetic markers of multidrug resistance (MDR) in Mycobacterium tuberculosis (Mtb) and establish statistical associations among identified mutations to enhance understanding of MDR in Mtb and inform diagnostic and treatment development. (2) Methods: GWAS analysis and the statistical evaluation of identified polymorphic sites within protein-coding genes of Mtb were performed. Statistical associations between specific mutations and antibiotic resistance were established using attributable risk statistics. (3) Results: Sixty-four polymorphic sites were identified as universal markers of drug resistance, with forty-seven in PE/PPE regions and seventeen in functional genes. Mutations in genes such as cyp123, fadE36,

SUBMITTER: Hlanze H 

PROVIDER: S-EPMC11278869 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature