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Epidemiology and Genetic Characterization of Leishmania RNA Virus in Leishmania (Viannia) spp. Isolates from Cutaneous Leishmaniasis Endemic Areas in Panama.

ABSTRACT: Leishmania (Viannia) spp. can harbor a double-stranded RNA virus known as Leishmania RNA virus 1 (LRV-1), whose presence has been reported in nine countries across the Americas and seven Leishmania species. Here, we studied 100 Leishmania (Viannia) isolates from patients with cutaneous leishmaniasis collected from different endemic areas in Panama from 2016 to 2022. We identified L. (V.) panamensis, L. (V.) guyanensis, L. (V.) braziliensis/guyanensis hybrid, and L. (V.) panamensis sp.1. (genetic variant). LRV-1 was detected by RT-PCR in 9% of L. (Viannia) isolates (eight cases in L. (V.) panamensis, and one in L. (V.) guyanensis). Phylogenetic analysis based on sequencing data classified all LRV-1 isolates within genotype A, suggesting that LRV phylogenetic proximity is closely aligned with geographical distribution or to the phylogenetic proximity of the Leishmania host in the case of the L. (V.) panamensis and L. (V.) guyanensis in Panama.

SUBMITTER: Bonilla AA 

PROVIDER: S-EPMC11279101 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature

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Epidemiology and Genetic Characterization of <i>Leishmania</i> RNA Virus in <i>Leishmania</i> (<i>Viannia</i>) spp. Isolates from Cutaneous Leishmaniasis Endemic Areas in Panama.

Bonilla Armando Assair AA   Pineda Vanessa V   Calzada José Eduardo JE   Saldaña Azael A   Laurenti Marcia Dalastra MD   Goya Stephanie S   Abrego Leyda L   González Kadir K  

Microorganisms 20240627 7

<i>Leishmania</i> (<i>Viannia</i>) spp. can harbor a double-stranded RNA virus known as Leishmania RNA virus 1 (LRV-1), whose presence has been reported in nine countries across the Americas and seven <i>Leishmania</i> species. Here, we studied 100 <i>Leishmania</i> (<i>Viannia</i>) isolates from patients with cutaneous leishmaniasis collected from different endemic areas in Panama from 2016 to 2022. We identified <i>L.</i> (<i>V.</i>) <i>panamensis</i>, <i>L.</i> (<i>V.</i>) <i>guyanensis</i>,  ...[more]

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