Genetic Homogeneity of <i>Francisella tularensis</i> subsp. <i>mediasiatica</i> Strains in Kazakhstan.

ABSTRACT: Tularemia is an acute febrile disease caused by the Gram-negative bacillus Francisella tularensis. Based on genetic and phenotypic characteristics, three subspecies are distinguished: tularensis, holarctica, and mediasiatica. F. tularensis subsp. mediasiatica remains the least studied subspecies. Over the past decade, new foci of distribution of F. tularensis subsp. mediasiatica have been discovered in Russia (Siberia), expanding the possible distribution area by thousands of kilometers. This article provides whole genome single nucleotide polymorphism (wgSNP) and polymorphic tandem repeats (MLVA) analyses of 28 mediasiatica strains isolated between 1965 and 2004 in Kazakhstan. Despite high genetic homogeneity, MLVA with eleven

SUBMITTER: Shevtsov A 

PROVIDER: S-EPMC11279412 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature