Sex-biased gene regulation varies across human populations as a result of adaptive evolution.

ABSTRACT:

Objectives

Studies of human sexual dimorphism and gender disparities in health focus on ostensibly universal molecular sex differences, such as sex chromosomes and circulating hormone levels, while ignoring the extraordinary diversity in biology, behavior, and culture acquired by different human populations over their unique evolutionary histories.

Materials and methods

Using RNA-Seq data and whole genome sequences from 1000G and HGDP, we investigate variation in sex-biased gene expression across 11 human populations and test whether population-level variation in sex-biased expression may have resulted from adaptive evolution in regions containing sex-specific regulatory variants.

Results

We find that sex-biased gene expression in humans is highly variable, mostly pop

SUBMITTER: Reynolds AZ 

PROVIDER: S-EPMC11279473 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature