The Genomic Epidemiology of Clinical <i>Burkholderia pseudomallei</i> Isolates in North Queensland, Australia.

ABSTRACT: Background:Burkholderia pseudomallei, the causative agent of melioidosis, is highly genetically recombinant, resulting in significant genomic diversity. Multiple virulence factors have been associated with specific disease presentations. To date, there are limited data relating to genomic diversity and virulence factors associated with melioidosis cases in North Queensland, Australia. Aim: To describe the genetic diversity of B. pseudomallei and identify virulence factors associated with clinical risk factors and patient outcomes. Methods: Whole genome sequencing of clinical isolates was performed and analysed with clinical data obtained from a retrospective melioidosis cohort study. Results: Fifty-nine distinct sequence types (STs) were identified

SUBMITTER: Gassiep I 

PROVIDER: S-EPMC11279585 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature