Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

ABSTRACT: Despite significant progress in cancer prevention, screening, and treatment, the still limited number of therapeutic options is an obstacle towards increasing the cancer cure rate. In recent years, many efforts were put forth to develop therapeutics that selectively target different components of the oncogenic Wnt/β-catenin signaling pathway. These include small molecule inhibitors, antibodies, and more recently, gene-based approaches. Although some of them showed promising outcomes in clinical trials, the Wnt/β-catenin pathway is still not targeted in routine clinical practice for cancer management. As for most anticancer treatments, a critical limitation to the use of Wnt/β-catenin inhibitors is their therapeutic index, i.e., the difficulty of combining effective anticancer activity with

SUBMITTER: de Pellegars-Malhortie A 

PROVIDER: S-EPMC11279613 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature