Impact of Microbiota and Metabolites on Intestinal Integrity and Inflammation in Severe Obesity.

ABSTRACT: Obesity is a multifactorial disease associated with low-grade inflammation. The gut is thought to be involved in obesity-related inflammation, as it is continuously exposed to antigens from food, microbiota and metabolites. However, the exact underlying mechanisms are still unknown. Therefore, we examined the relation between gut pathology, microbiota, its metabolites and cytokines in adults with severe obesity. Individuals eligible for bariatric surgery were included. Fecal and plasma samples were collected at surgery timepoint, to assess microbiota and metabolite composition. Jejunal biopsies were collected during surgery and stained for cytotoxic T cells, macrophages, mast cells and tight junction component zonula occludens-1. Based on these stainings, the cohort was divided into four g

SUBMITTER: Custers E 

PROVIDER: S-EPMC11279642 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature