Naturally Derived Terpenoids Targeting the 3D^pol of Foot-and-Mouth Disease Virus: An Integrated In Silico and In Vitro Investigation.

ABSTRACT: Foot-and-mouth disease virus (FMDV) belongs to the Picornaviridae family and is an important pathogen affecting cloven-hoof livestock. However, neither effective vaccines covering all serotypes nor specific antivirals against FMDV infections are currently available. In this study, we employed virtual screening to screen for secondary metabolite terpenoids targeting the RNA-dependent RNA polymerase (RdRp), or 3D^pol, of FMDV. Subsequently, we identified the potential antiviral activity of the 32 top-ranked terpenoids, revealing that continentalic acid, dehydroabietic acid (abietic diterpenoids), brusatol, bruceine D, and bruceine E (tetracyclic triterpenoids) significantly reduced cytopathic effects and viral infection in the terpenoid-treated, FMDV-infected BHK-21 cells in

SUBMITTER: Mana N 

PROVIDER: S-EPMC11281344 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature