Transovarial Transmission of Cell-Fusing Agent Virus in Naturally Infected <i>Aedes aegypti</i> Mosquitoes.

ABSTRACT: Mosquito-borne arboviruses include several pathogens that are responsible for many diseases of significant public health burden. Mosquitoes also host many insect-specific viruses that cannot replicate in vertebrate cells. These insect-specific viruses persist in nature predominantly via vertical transmission (VT), and they exhibit high VT rates (VTRs). Cell-fusing agent virus (CFAV), an insect-specific orthoflavivirus, shows high VTRs in naturally infected mosquitoes but not in artificially infected mosquitoes. To determine whether the high VTRs are due to transovarial transmission, we investigated VT and ovary infection patterns in naturally CFAV-infected Aedes aegypti (Bangkok) mosquitoes. VT was monitored by detecting CFAV among the progeny by reverse-transcription polymerase cha

SUBMITTER: Nag DK 

PROVIDER: S-EPMC11281400 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature