Identification and Functional Implications of the E5 Oncogene Polymorphisms of Human Papillomavirus Type 16.

ABSTRACT: The persistence of the human papillomavirus type 16 (HPV16) infection on the cervical epithelium contributes to the progression of cervical cancer. Studies have demonstrated that HPV16 genetic variants may be associated with different risks of developing cervical cancer. However, the E5 oncoprotein of HPV16, which is related to several cellular mechanisms in the initial phases of the infection and thus contributes to carcinogenesis, is still little studied. Here we investigate the HPV16 E5 oncogene variants to assess the effects of different mutations on the biological function of the E5 protein. We detected and analyzed the HPV16 E5 oncogene polymorphisms and their phylogenetic relationships. After that, we proposed a tertiary structure analysis of the protein variants, preferential codon

SUBMITTER: da Silva-Junior AHP 

PROVIDER: S-EPMC11281449 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature