Dihydropyridine Calcium Channel Blockers and Kidney Outcomes.

ABSTRACT:

Background

Early trials of dihydropyridine calcium channel blockers (DCCBs) suggest a detrimental effect on intraglomerular pressure and an association with albuminuria.

Objective

We sought to evaluate the associations of DCCB initiation with albuminuria and kidney failure with replacement therapy (KFRT) and to determine whether renin-angiotensin system (RAS) blockade modified these associations.

Design

We conducted a target trial emulation study using a new user, active comparator design and electronic health record data from Geisinger Health.

Participants

We included patients without severe albuminuria or KFRT who were initiated on a DCCB or thiazide (active comparator) between January 1, 2004, and December 31, 2019.

Main measures

Using inverse probabi

SUBMITTER: Blum MF 

PROVIDER: S-EPMC11282043 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature