ER-Targeted PET for Initial Staging and Suspected Recurrence in ER-Positive Breast Cancer.

ABSTRACT:

Importance

There are insufficient data comparing 16α-18F-fluoro-17β-estradiol (FES) positron emission tomography (PET) computed tomography (CT) with standard-of-care imaging (SOC) for staging locally advanced breast cancer (LABC) or evaluating suspected recurrence.

Objective

To determine the detection rate of FES PET/CT and SOC for distant metastases in patients with estrogen receptor (ER)-positive LABC and recurrences in patients with ER-positive BC and suspected recurrence.

Design, setting, and participants

This diagnostic study was conducted as a single-center phase 2 trial, from January 2021 to September 2023. The study design provided 80% power to find a 20% detection rate difference. Participants included patients with ER-positive LABC (cohort 1) or suspected re

SUBMITTER: Ulaner GA 

PROVIDER: S-EPMC11282447 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature