Retinal primary cilia and their dysfunction in retinal neurodegenerative diseases: beyond ciliopathies.

ABSTRACT: Primary cilia are sensory organelles that extend from the cellular membrane and are found in a wide range of cell types. Cilia possess a plethora of vital components that enable the detection and transmission of several signaling pathways, including Wnt and Shh. In turn, the regulation of ciliogenesis and cilium length is influenced by various factors, including autophagy, organization of the actin cytoskeleton, and signaling inside the cilium. Irregularities in the development, maintenance, and function of this cellular component lead to a range of clinical manifestations known as ciliopathies. The majority of people with ciliopathies have a high prevalence of retinal degeneration. The most common theory is that retinal degeneration is primarily caused by functional and developmental prob

SUBMITTER: Liu X 

PROVIDER: S-EPMC11282803 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature