Uncovering the role of the subcommissural organ in early brain development through transcriptomic analysis.

ABSTRACT:

Background

The significant role of embryonic cerebrospinal fluid (eCSF) in the initial stages of brain development has been thoroughly studied. This fluid contains crucial molecules for proper brain development such as members of the Wnt and FGF families, apolipoproteins, and retinol binding protein. Nevertheless, the source of these molecules remains uncertain since they are present before the formation of the choroid plexus, which is conventionally known as the primary producer of cerebrospinal fluid. The subcommissural organ (SCO) is a highly conserved gland located in the diencephalon and is one of the earliest differentiating brain structures. The SCO secretes molecules into the eCSF, prior to the differentiation of the choroid plexus, playing a pivotal role in the homeostasis

SUBMITTER: Gonzalez M 

PROVIDER: S-EPMC11282827 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature