The Efficacy of Risk Factor Modification Compared to NAD⁺ Repletion in Diastolic Heart Failure.

ABSTRACT: Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD⁺) levels in human systolic and diastolic HF and in a murine model of HF with preserved ejection fraction, exploring NAD⁺ repletion as therapy. We quantified myocardial NAD⁺ and nicotinamide phosphoribosyltransferase levels, assessing restoration with nicotinamide riboside (NR). Findings show significant NAD⁺ and nicotinamide phosphoribosyltransferase depletion in human diastolic HF myocardium, but NR successfully restored NAD⁺ levels. In murine HF with preserved ejection fraction, NR as preventive and therapeutic intervention improved metabolic and antioxidant profil

SUBMITTER: Koay YC 

PROVIDER: S-EPMC11282886 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature