Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.

ABSTRACT:

Background

The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS).

Methods

A case-control dataset was generated consisting of 4002 lung cancer cases from the LORD project and 20,010 ethnically matched controls from CARTaGENE. A genome-wide PRS including >1.1 million genetic variants was derived and validated in UK Biobank (n = 5419 lung cancer cases). The predictive ability and diagnostic discrimination performance of the PRS was tested in LORD/CARTaGENE and benchmarked against previous PRSs from the literature. Stratified analyses were performed by smoking status and genetic risk groups defined as low (<20th percentile), intermediate (20-80th percentile) and high (>80th percentile) PRS.

Findings

The p

SUBMITTER: Boumtje V 

PROVIDER: S-EPMC11282926 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature